Brees was 29 of 43 for 382 yards and completed his 1,850th pass as a Saint in the second quarter to break a record held by Archie Manning since 1982.
Brees shredded the Seahawks (5-5) without the benefit of having Reggie Bush, Pierre Thomas and tight end Jeremy Shockey in the lineup. Yet he still managed to complete passes to 10 different receivers, including rookie tight end Jimmy Graham, who made five catches for 72 yards.
Brees' accuracy helped the Saints go 11 of 15 on third downs. He eclipsed 300 yards by the third quarter, marking the 35th time as a Saint, which extended his own franchise mark.
Now in his fifth season in New Orleans, Brees owns numerous franchise passing records, including TDs with 144, but still has another significant one that he'll probably surpass this season. Manning's 21,734 yards passing remains a club record, but Brees is less than 500 yards behind at 21,267.